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Breast Cancer Angiogenesis

Green Tea Inhibits Breast Cancer Angiogenesis At Genetic Level

Many studies on green tea and breast cancer have shown evidence that green tea reduces the risk of breast cancer.

But researchers are still working to understand all the cellular mechanisms involved.

A new study examined the effects of green tea extract on blood vessel growth (neovascularization or angiogenesis) in breast cancer cells.

Angiogenesis is necessary for cancer progression, and stopping angiogenesis is one goal of cancer treatments.

Scientists at the University of Chicago found that green tea extract

• inhibited breast cancer cell migration

• inhibited the expression of vascular endothelial growth factor and matrix metalloproteinase 9

• inhibited VEGF-induced neovascularization

• blocked signal transducers and activators of transcription signaling

• blocked STAT3 activation by inhibiting STAT1 and STAT3 dimerization

• and suppressed interferon-gamma-induced gene transcription.

They concluded that green tea extract disrupts STAT3-mediated transcription of genes, thus reducing angiogenesis in breast cancer cells (Leong H, Green tea catechins inhibit angiogenesis through suppression of STAT3 activation, Breast Cancer Research and Treatment, September 2008).

This study is considered preliminary and more research is needed to confirm all the cellular mechanisms involved in green tea breast cancer risk reduction research.

Currently, one out of eight women are expected to develop breast cancer sometime in their lives.

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This page last updated by Sharon Jones.

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